Upload at 2018-04-03 15:06:19
Causal Biological Networks Database
The Notch network depicts the causal mechanisms that regulate Notch signaling, which controls lung cell proliferation and differentiation through DLK1 (an upstream initiator of the Notch signaling pathway) and JAG1/2 (ligands for the Notch receptors).
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Number Nodes
Number Edges
Number Components
Network Density
Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 73%
Colorectal Cancer Model v2.0.6 35%
Selventa Protein Families Definitions v20150611 31%
Notch-2.0-Mm v2.0 31%
CRC_combined v1.1 29%
BEL Framework Small Corpus Document v20150611 27%
Growth Factor-2.0-Hs v2.0 25%
Notch-2.0-Rn v2.0 25%
CRC_combined.bel v1.0 25%
Th1-Th2 Signaling-2.0-Hs v2.0 21%

Sample Edges

p(HGNC:JAG1) directlyIncreases act(p(SFAM:"NOTCH Family"), ma(tscript))

we show that activation of the Notch pathway by the ligand Jagged1 reduces the proliferation of endothelial cells. PubMed:15456857

p(HGNC:JAG1) directlyIncreases act(p(SFAM:"NOTCH Family"), ma(tscript))

Notch signaling is important for Th2 differentiation.44, 45 It has been shown that Jag1/Notch interaction induces Th2 differentiation.whereas Dll1/Notch interaction results in Th1 polarization.44 PubMed:20065998

p(HGNC:JAG1) directlyIncreases act(p(SFAM:"NOTCH Family"), ma(tscript))

mTOR positively regulates the mRNA expression of Notch ligand Jagged1. PubMed:20038814

p(HGNC:JAG1) directlyIncreases act(p(SFAM:"NOTCH Family"), ma(tscript))

To generate tools for pursuing the role of the Notch pathway in human disease and development, we have cloned and analyzed the expression of three human homologues of the Notch ligands Delta and Serrate, human Jagged1 (HJ1), human Jagged2 (HJ2), and human Delta1 (H-Delta-1), and determined their chromosomal localizations. PubMed:10079256

Sample Nodes


In-Edges: 170 | Out-Edges: 194 | Explore Neighborhood | Download JSON


In-Edges: 267 | Out-Edges: 239 | Explore Neighborhood | Download JSON


In-Edges: 77 | Out-Edges: 196 | Explore Neighborhood | Download JSON


In-Edges: 869 | Out-Edges: 721 | Explore Neighborhood | Download JSON


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