Provenance

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charles.hoyt@scai.fraunhofer.de at 2018-04-03 15:06:19
Authors
Causal Biological Networks Database
Contact
CausalBiologicalNetworks.RD@pmi.com
Description
The Notch network depicts the causal mechanisms that regulate Notch signaling, which controls lung cell proliferation and differentiation through DLK1 (an upstream initiator of the Notch signaling pathway) and JAG1/2 (ligands for the Notch receptors).
License
Please cite: - www.causalbionet.com - https://bionet.sbvimprover.com as well as any relevant publications. The sbv IMPROVER project, the website and the Symposia are part of a collaborative project designed to enable scientists to learn about and contribute to the development of a new crowd sourcing method for verification of scientific data and results. The current challenges, website and biological network models were developed and are maintained as part of a collaboration among Selventa, OrangeBus and ADS. The project is led and funded by Philip Morris International. For more information on the focus of Philip Morris International’s research, please visit www.pmi.com.
Number Nodes
48
Number Edges
111
Number Components
4
Network Density
0.0492021
Average Degree
2.3125
Number Citations
48
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 73%
Colorectal Cancer Model v2.0.6 35%
Selventa Protein Families Definitions v20150611 31%
Notch-2.0-Mm v2.0 31%
CRC_combined v1.1 29%
BEL Framework Small Corpus Document v20150611 27%
Growth Factor-2.0-Hs v2.0 25%
Notch-2.0-Rn v2.0 25%
CRC_combined.bel v1.0 25%
Th1-Th2 Signaling-2.0-Hs v2.0 21%

Sample Edges

p(HGNC:JAG1) directlyIncreases act(p(SFAM:"NOTCH Family"), ma(tscript))

we show that activation of the Notch pathway by the ligand Jagged1 reduces the proliferation of endothelial cells. PubMed:15456857

p(HGNC:JAG1) directlyIncreases act(p(SFAM:"NOTCH Family"), ma(tscript))

Notch signaling is important for Th2 differentiation.44, 45 It has been shown that Jag1/Notch interaction induces Th2 differentiation.whereas Dll1/Notch interaction results in Th1 polarization.44 PubMed:20065998

p(HGNC:JAG1) directlyIncreases act(p(SFAM:"NOTCH Family"), ma(tscript))

mTOR positively regulates the mRNA expression of Notch ligand Jagged1. PubMed:20038814

p(HGNC:JAG1) directlyIncreases act(p(SFAM:"NOTCH Family"), ma(tscript))

To generate tools for pursuing the role of the Notch pathway in human disease and development, we have cloned and analyzed the expression of three human homologues of the Notch ligands Delta and Serrate, human Jagged1 (HJ1), human Jagged2 (HJ2), and human Delta1 (H-Delta-1), and determined their chromosomal localizations. PubMed:10079256

Sample Nodes

p(HGNC:MYC)

In-Edges: 170 | Out-Edges: 194 | Explore Neighborhood | Download JSON

p(HGNC:AKT1)

In-Edges: 267 | Out-Edges: 239 | Explore Neighborhood | Download JSON

p(HGNC:IL4)

In-Edges: 77 | Out-Edges: 196 | Explore Neighborhood | Download JSON

p(HGNC:BACE1)

In-Edges: 869 | Out-Edges: 721 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of the open source project, PyBEL. Please feel free to contact us here to give us feedback or report any issues.