### Unstable Pairs 3

Chaotic Pairs
Nodes that mutually increase each other, such as when both `A increases B` and ```B increases A```.
Dampened Pairs
Nodes that mutually decrease each other, such as when both `A decreases B` and ```B decreases A```.

While neither chaotic nor dampened pairs are biologically invalid, they require additional context to understand their regulation.

Type Node A Node B
Dampened p(RGD:Hif1a) p(RGD:Hif1a)
Dampened p(RGD:Hif3a) p(RGD:Hif3a)
Dampened p(RGD:Epas1) p(RGD:Epas1)

Analysis of triple stability comes from a deep graph theoretic background. It identifies triangles within the graph that have logically inconsistent relations.

Separately Unstable Triplet
When both `A positiveCorrelation B`, `B negativeCorrelation C`, but `C positiveCorrelation A`.
Mutually Unstable Triplets
When both `A negativeCorrelation B`, `B negativeCorrelation C`, and `C negativeCorrelation A`.
When `A increases B`, `A decreases C`, and ```C positiveCorrelation A```.
Increase Mismatch Triplet
When `A increases B`, `A increases C`, and ```C negativeCorrelation A```.
Decrease Mismatch Triplet
When `A decreases B`, `A decreases C`, and ```C negativeCorrelation A```.
Type Node A Node B Node C
Jens p(RGD:Hif3a) p(RGD:Hif3a) p(RGD:Hif3a)
Jens p(RGD:Epas1) p(RGD:Epas1) p(RGD:Epas1)
Jens a(SCHEM:Oxygen) bp(GOBP:"response to hypoxia") p(RGD:Egln1)
Jens a(SCHEM:Oxygen) bp(GOBP:"response to hypoxia") p(RGD:Egln3)
Jens a(SCHEM:Oxygen) bp(GOBP:"response to hypoxia") p(RGD:Egln2)
Jens p(RGD:Hif1a) p(RGD:Hif1a) p(RGD:Hif1a)

### Causal Pathologies 5

Pathologies are more dogmatically the result of molecular and physical processes, and do not necessarily make sense as the subject of causal statements.

Source Relation Target
path(MESHD:"Pulmonary Disease, Chronic Obstructive") increases m(RGD:Egln1)
path(MESHD:"Pulmonary Disease, Chronic Obstructive") increases m(RGD:Egln3)
path(MESHD:"Pulmonary Disease, Chronic Obstructive") increases m(RGD:Hif1a)
path(MESHD:"Pulmonary Disease, Chronic Obstructive") decreases p(RGD:Egln2)
path(MESHD:"Pulmonary Disease, Chronic Obstructive") increases p(RGD:Hif1a)