Table of Contents

Unstable Pairs 3

Chaotic Pairs
Nodes that mutually increase each other, such as when both A increases B and B increases A.
Dampened Pairs
Nodes that mutually decrease each other, such as when both A decreases B and B decreases A.

While neither chaotic nor dampened pairs are biologically invalid, they require additional context to understand their regulation.

Type Node A Node B
Dampened p(RGD:Hif1a) p(RGD:Hif1a)
Dampened p(RGD:Hif3a) p(RGD:Hif3a)
Dampened p(RGD:Epas1) p(RGD:Epas1)

Contradictory Triplets 6

Analysis of triple stability comes from a deep graph theoretic background. It identifies triangles within the graph that have logically inconsistent relations.

Separately Unstable Triplet
When both A positiveCorrelation B, B negativeCorrelation C, but C positiveCorrelation A.
Mutually Unstable Triplets
When both A negativeCorrelation B, B negativeCorrelation C, and C negativeCorrelation A.
Jens Contradictory Triplet
When A increases B, A decreases C, and C positiveCorrelation A.
Increase Mismatch Triplet
When A increases B, A increases C, and C negativeCorrelation A.
Decrease Mismatch Triplet
When A decreases B, A decreases C, and C negativeCorrelation A.
Type Node A Node B Node C
Jens p(RGD:Hif3a) p(RGD:Hif3a) p(RGD:Hif3a)
Jens p(RGD:Epas1) p(RGD:Epas1) p(RGD:Epas1)
Jens a(SCHEM:Oxygen) bp(GOBP:"response to hypoxia") p(RGD:Egln1)
Jens a(SCHEM:Oxygen) bp(GOBP:"response to hypoxia") p(RGD:Egln3)
Jens a(SCHEM:Oxygen) bp(GOBP:"response to hypoxia") p(RGD:Egln2)
Jens p(RGD:Hif1a) p(RGD:Hif1a) p(RGD:Hif1a)

Causal Pathologies 5

Pathologies are more dogmatically the result of molecular and physical processes, and do not necessarily make sense as the subject of causal statements.

Source Relation Target
path(MESHD:"Pulmonary Disease, Chronic Obstructive") increases m(RGD:Egln1)
path(MESHD:"Pulmonary Disease, Chronic Obstructive") increases m(RGD:Egln3)
path(MESHD:"Pulmonary Disease, Chronic Obstructive") increases m(RGD:Hif1a)
path(MESHD:"Pulmonary Disease, Chronic Obstructive") decreases p(RGD:Egln2)
path(MESHD:"Pulmonary Disease, Chronic Obstructive") increases p(RGD:Hif1a)

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