Table of Contents

Unstable Pairs 1

Chaotic Pairs
Nodes that mutually increase each other, such as when both A increases B and B increases A.
Dampened Pairs
Nodes that mutually decrease each other, such as when both A decreases B and B decreases A.

While neither chaotic nor dampened pairs are biologically invalid, they require additional context to understand their regulation.

Type Node A Node B
Chaotic p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))

Contradictory Triplets 2

Analysis of triple stability comes from a deep graph theoretic background. It identifies triangles within the graph that have logically inconsistent relations.

Separately Unstable Triplet
When both A positiveCorrelation B, B negativeCorrelation C, but C positiveCorrelation A.
Mutually Unstable Triplets
When both A negativeCorrelation B, B negativeCorrelation C, and C negativeCorrelation A.
Jens Contradictory Triplet
When A increases B, A decreases C, and C positiveCorrelation A.
Increase Mismatch Triplet
When A increases B, A increases C, and C negativeCorrelation A.
Decrease Mismatch Triplet
When A decreases B, A decreases C, and C negativeCorrelation A.
Type Node A Node B Node C
Jens p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.