act(p(HGNC:GAL)) increases r(HGNC:CHAT)

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PubMed:18986241

For example, the neuropeptide GAL, which functions via the interaction with three G protein-coupled receptors termed GALR1, GALR2 and GALR3, has multiple biological actions, including effects on cognition and neuroplasticity [15,146,147]. In the late [148–150] but not early [151] stage of AD, fibers within the basal forebrain containing the neuropeptide GAL thicken and hyperinnervate surviving CBF neurons. Although animal and cell-culture studies have shown that GAL plays a crucial role in the regulation of CBF neuron activity [152] and rescues cholinergic cells from amyloid toxicity [153], the molecular consequences of this unique plasticity response upon CBF neurons in AD remain unclear. Gene expression studies of cholinergic transcripts have shown that GAL hyperinnervated, but not nonhyperinnervated, CBF neurons display an upregulation of ChAT expression in AD compared to controls [126]

Related Edges 7

• bp(MESH:D009473) association act(p(HGNC:GAL))
• act(p(HGNC:GAL)) association path(MESH:D003071)
• act(p(HGNC:GAL)) association bp(MESH:D009473)
• act(p(HGNC:GAL)) increases bp(GO:"GO:0060384")
• act(p(HGNC:GAL)) regulates act(a(MESH:D059329))
• act(p(HGNC:GAL)) decreases a(CHEBI:"amyloid-beta")
• path(MESH:D003071) association act(p(HGNC:GAL))

Disease Ontology (DO)

Alzheimer's disease

MeSH

Basal Forebrain

MeSH

Cholinergic Neurons

MeSH

Cognitive Dysfunction

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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