bp(GO:"GO:0000165") increases act(p(HGNC:MAPKAPK2))

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PubMed:18986241

The classic MAPK cascade involves activation of the small GTPase Ras, and the kinases Raf and MEK [86,87]. Downstream consequences of MAPK activation include activation of the ribosomal S6 kinases (Rsk) and the MAPK-activated protein kinase 2 (MAPKAP2), which phosphorylates several transcription factors including Elk-1 and cAMP-regulated response element binding protein (CREB) [85]. The physiological significance of this elaborate NGF-induced network remains unclear, but the sustained activation of MAPK is linked to neurotrophin-mediated neurite outgrowth [88,89]

Related Edges 8

• bp(GO:"GO:0000165") increases act(p(FPLX:RAS))
• bp(GO:"GO:0000165") increases act(p(FPLX:RAF))
• bp(GO:"GO:0000165") increases act(p(FPLX:MEK))
• bp(GO:"GO:0000165") increases act(p(FPLX:P90RSK))
• bp(GO:"GO:0031175") association act(p(GFAM:"Mitogen-activated protein kinases"))
• act(p(GFAM:"Mitogen-activated protein kinases")) association bp(GO:"GO:0031175")
• act(p(HGNC:MAPKAPK2)) increases p(HGNC:ELK1, pmod(Ph))
• act(p(HGNC:MAPKAPK2)) increases p(HGNC:CREB1, pmod(Ph))

MeSH

Cognitive Dysfunction

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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