a(CHEBI:"amyloid-beta") decreases act(p(HGNC:BCL2))

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PubMed:19293145

AKT interacts with BAD to regulate apoptosis and, interestingly, also has many interacting partners in the insulin signaling pathway. Abeta increased activity of BAD, lowered the activity of the antiapoptotic protein BCL2, in rat hippocampal neurons in primary culture (Koriyama et al., 2003) and has been shown to be toxic to human neuroblastoma cells by increasing BAX activity and decreasing BCl-2 activity (Clementi et al., 2006).

Related Edges 5

• a(CHEBI:"amyloid-beta") increases act(p(HGNC:BAX))
• a(CHEBI:"amyloid-beta") increases act(p(HGNC:BAD))
• bp(GO:"insulin receptor signaling pathway") association p(FPLX:AKT)
• p(FPLX:AKT) association bp(GO:"insulin receptor signaling pathway")
• complex(p(FPLX:AKT), p(HGNC:BAD)) regulates bp(GO:"apoptotic process")

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