a(HBP:"beta-2-containing nAChR") association a(CHEBI:nicotine)

PubMed:19126755

The concept that beta2-containing nAChRs are involved in the reinforcing effects of nicotine was supported by the findings that these mice lacked the high-affinity nicotine binding site, exhibited poor nicotine self-administration, and failed to develop behaviors related to reinforcement (378). The demonstration that these mice developed symptoms of the nicotine withdrawal syndrome similar to those observed in wild-type mice led to the conclusion that beta2-containing nAChRs do not contribute to the physical dependence on nicotine (57).

Related Edges 2

• a(CHEBI:nicotine) association a(HBP:"beta-2-containing nAChR")
• a(HBP:"beta-2-containing nAChR") causesNoChange act(a(CHEBI:nicotine))

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