p(MGI:Casp1) decreases bp(GO:cognition)

View Subject View Object

PubMed:24561250

In support, knockout of NLRP3 and caspase-1 have been shown to suppress amyloidogenesis and neuropathology, and improve cognition in AD transgenic mice (Heneka et al., 2013)

Related Edges 5

• p(MGI:Casp1) increases bp(GO:"amyloid-beta formation")
• p(MGI:Casp1) increases a(MESH:Neuropathology)
• p(MGI:Nlrp3) increases bp(GO:"amyloid-beta formation")
• p(MGI:Nlrp3) increases a(MESH:Neuropathology)
• p(MGI:Nlrp3) decreases bp(GO:cognition)

Confidence

High

MeSH

Alzheimer Disease

NeuroMMSigDB

Caspase subgraph

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---