act(p(HGNC:MAP3K5)) association p(HGNC:CASP3)

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PubMed:27068745

Overexpression of wild-type UNC5C causes low-grade death, intensified by an AD-linked mutation T835M inhibited by a AD-linked survival factor, calmodulin-like skin protein (CLSP), and a natural ligand of UNC5C, netrin1. T835M-UNC5C-induced neuronal cell death is mediated by an intracellular death-signaling cascade, consisting of DAPK1/protein kinase D/apoptosis signal-regulating kinase 1 (ASK1)/JNK/NADPH oxidase/caspases, which merges at ASK1 with a death-signaling cascade, mediated by amyloid ß precursor protein (APP).

Related Edges 16

• bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:UNC5C)
• p(ECCODE:"1.6.3.1") positiveCorrelation act(p(FPLX:JNK))
• act(p(FPLX:JNK)) positiveCorrelation p(ECCODE:"1.6.3.1")
• act(p(FPLX:JNK)) association p(HGNC:CASP3)
• p(HGNC:CALML5) decreases p(HGNC:UNC5C, var("p.Thr835Met"))
• p(HGNC:CASP3) association act(p(FPLX:JNK))
• p(HGNC:CASP3) association act(p(HGNC:MAP3K5))
• p(HGNC:CASP3) increases bp(GO:"neuron apoptotic process")
• act(p(HGNC:MAP3K5)) positiveCorrelation act(p(HGNC:PRKD1))
• act(p(HGNC:MAP3K5)) increases act(p(FPLX:JNK))
• p(HGNC:NTN1) decreases p(HGNC:UNC5C, var("p.Thr835Met"))
• act(p(HGNC:PRKD1)) positiveCorrelation p(HGNC:UNC5C, var("p.Thr835Met"))
• act(p(HGNC:PRKD1)) positiveCorrelation act(p(HGNC:MAP3K5))
• p(HGNC:UNC5C) positiveCorrelation bp(GO:"neuron apoptotic process")
• p(HGNC:UNC5C, var("p.Thr835Met")) increases bp(GO:"neuron apoptotic process")
• p(HGNC:UNC5C, var("p.Thr835Met")) positiveCorrelation act(p(HGNC:PRKD1))

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