act(p(HGNC:PPP2CA)) negativeCorrelation p(HGNC:MAPT, pmod(Ph))

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PubMed:29062069

Here we show that resveratrol treatment directly interferes with the MID1-α4-PP2A degradation complex by reducing MID1 protein expression in vitro and in vivo. This leads to an increase of microtubule-associated PP2A activity and a time- and dose-dependent dephosphorylation of Tau. Interestingly, we further show that MID1 expression is elevated in AD tissue.

Related Edges 4

• a(CHEBI:resveratrol) directlyIncreases act(p(HGNC:PPP2CA))
• a(CHEBI:resveratrol) directlyDecreases p(HGNC:MID1)
• p(HGNC:MAPT, pmod(Ph)) negativeCorrelation act(p(HGNC:PPP2CA))
• p(HGNC:MID1) decreases act(p(HGNC:PPP2CA))

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