a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, frag("?", "24kD"))

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PubMed:24027553

Also, treating primary hippocampal neurons with pre-aggregated amyloid beta (Abeta) led to the generation of tau fragments of ∼35, ∼24, and ∼17 kDa, which was blocked by addition of a calpain inhibitor (52, 53). Tau fragments of the same size were also found in AD brain tissue (19).

Related Edges 6

• a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, frag("?", "17kD"))
• a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, frag("?", "35kD"))
• a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "17kD"))
• a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "35kD"))
• a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "24kD"))
• a(CHEBI:"calpain inhibitor") decreases act(p(HGNCGENEFAMILY:Calpains))

MeSH

Hippocampus

MeSH

Alzheimer Disease

Text Location

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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