a(CHEBI:nicotine) decreases act(a(CHEBI:"NS-398"))

PubMed:19126755

A link between alpha4 nAChRs and Cox2 was suggested by the observation that interneurons in the hippocampus coexpress both proteins (165). A mechanistic connection was inferred when long-term treatment of aged animals with NS398 promoted retention of alpha4 nAChR expression in the brain, an effect that was antagonized by the coadministration of nicotine.

Related Edges 3

• a(CHEBI:"NS-398") decreases p(HGNC:CHRNA4)
• p(HGNC:CHRNA4) association p(HGNC:PTGS2)
• p(HGNC:PTGS2) association p(HGNC:CHRNA4)

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