act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases p(HGNC:MAPT, pmod(Ph))

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PubMed:19293145

It is also noteworthy that Abeta-induced tau protein phosphorylation in PC12 cells is inhibited not only by alpha7 agonists, as would be predicted from the role of alpha7 nAChRs in neuroprotection, but also by alpha-bungarotoxin (Hu et al., 2008), as might be predicted if the competition by alpha-bungarotoxin for the Abeta site blocked a direct action of Abeta on nAChRs. It is therefore possible that the toxicity of Abeta is mediated, at least in part, through a direct physical interaction between Abeta and nAChRs.

Related Edges 2

• a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, pmod(Ph))
• act(a(MESH:Bungarotoxins)) decreases p(HGNC:MAPT, pmod(Ph))

Experimental Factor Ontology (EFO)

PC12

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