a(CHEBI:"dimethyl fumarate") decreases a(HBP:Astrogliosis)

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PubMed:29121589

Astrocytes displayed enlarged bodies and ramifications (Type B morphology), consistent with a reactive state after TAUP301L expression in Nrf2+/+ and Nrf2−/− mice (Fig. 6A left panels). However, only astrocytes from Nrf2+/+ mice treated with DMF were maintained in a resting morphology (Type A) (Fig. 6A right panels). Concerning microglia, TAUP301L expression induced a very significant increase in IBA1+ microglia at the ipsilateral hippocampal side of Nrf2+/+ and Nrf2−/− mice (Fig. 7A), which was confirmed by stereological quantification (Fig. 7B). DMF treatment reduced significantly this microgliosis in Nrf2+/+ but not in Nrf2−/− mice, reinforcing the idea of NRF2-dependent anti-inflammatory effect

Related Edges 3

• a(CHEBI:"dimethyl fumarate") decreases a(HBP:Microgliosis)
• p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:Astrogliosis)
• p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:Microgliosis)

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