a(HBP:"Braak_Stage V") negativeCorrelation act(p(HGNC:GSK3B), ma(kin))

View Subject View Object

PubMed:28176663

We found that GSK3β mRNA was overexpressed only in patients with initial AD, with no effect on the levels of the protein. On the other hand, we unexpectedly observed the decrease of the inactive GSK3β in cortex from AD patients at Braak stages I-II, whereas considerable increase was observed in AD patients at stages V-VI compared to the control subjects.

Related Edges 5

• a(HBP:"Braak_Stage I") positiveCorrelation act(p(HGNC:GSK3B), ma(kin))
• a(HBP:"Braak_Stage II") positiveCorrelation act(p(HGNC:GSK3B), ma(kin))
• act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage I")
• act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage II")
• act(p(HGNC:GSK3B), ma(kin)) negativeCorrelation a(HBP:"Braak_Stage V")

MeSH

Alzheimer Disease

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---