p(HGNC:MAPT, var("p.D421E")) decreases bp(GO:"apoptotic process")

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PubMed:24027553

Furthermore, expressing a cleavage resistant form of tau (D421E) protects cells from apoptotic cell death (22). Another potential mechanism of inducing caspase-3 cleavage of tau is the presence of Aβ peptides. TauC3 is formed in primary cortical neurons after treatment with Aβ (23).

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• composite(p(HBP:"amyloid-beta oligomers"), p(HGNC:CASP3)) increases p(HBP:"Tau C3")

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