act(a(CHEBI:Thrombin)) increases act(p(HGNCGENEFAMILY:Caspases))

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PubMed:24027553

Thrombin signaling can also activate caspases (36). Proteasomal impairment appears to be upstream of caspase activation, as inhibiting the proteasome with epoxomicin (EPX) led to activation of caspase-3 in primary neurons (63) and in a neuroblastoma cell line expressing wild-type tau (64).

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• a(CHEBI:epoxomicin) increases act(p(HGNC:CASP3))

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