act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?"))

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PubMed:24027553

Caspase-6 was also shown to cleave the N-terminus of tau in vitro (24). Caspase-3, which is a key effector in the apoptotic cascade, cleaves tau predominantly at the C-terminal D421 site generating a fragment often referred to as tauC3 (22, 23).

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• act(p(HGNC:CASP6)) increases bp(GO:"apoptotic process")
• act(p(HGNC:CASP6)) increases p(HGNC:MAPT, var("p.D421*"))

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