p(HGNC:CASP1) increases act(p(HGNC:IL1B))

View Subject View Object

PubMed:28019679

Activation of NLRP3 leads to the generation of interleukin-1b (IL-1b) and interleukin 18 (IL-18), which are being cleaved by caspase-1 from their inactive precursors and subsequently

Related Edges 3

• act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B)
• act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL18)
• p(HGNC:CASP1) increases act(p(HGNC:IL18))

Confidence

Medium

NeuroMMSigDB

Caspase subgraph

NeuroMMSigDB

Interleukin signaling subgraph

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---