a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta")

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PubMed:24590577

When APP/PS1/tau triple transgenic (3×Tg) AD mice are treated with the selective M1 mAChR agonist AF267B, the endogenous level of BACE1 decreases via an unclear mechanism, accompanied by a decreased Abeta level[77]. However, another study found that stimulation of M1 mAChR upregulates BACE1 levels in SK-SH-SY5Y cells via the PKC and MAPK signaling cascades[78]. We recently found that M1 mAChR directly interacts with BACE1 and mediates its proteasomal degradation[79]. These results suggest that M1 mAChR modulates BACE1 in a mixed manner.

Related Edges 8

• a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(MGI:Bace1)
• bp(GO:"MAPK cascade") increases p(HGNC:BACE1)
• act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC))
• act(p(HGNC:CHRM1)) increases p(HGNC:BACE1)
• p(HGNC:CHRM1) regulates p(HGNC:BACE1)
• act(p(HGNC:CHRM1)) increases bp(GO:"MAPK cascade")
• complex(p(HGNC:BACE1), p(HGNC:CHRM1)) increases deg(p(HGNC:BACE1))
• act(p(FPLX:PKC)) increases p(HGNC:BACE1)

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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