act(a(CHEBI:nicotine)) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))

PubMed:19721446

Regardless of the exact effect of Abeta1–42 on receptor activity, it does seem to block the activation by nicotine and, consistent with the cytoprotective nature of this interaction, amyloid deposition limits neuroprotection151. This phenomenon may explain at least part of the neurotoxicity that is associated with Abeta1–42 (ReF. 156).

Related Edges 3

• a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity)
• a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(CHEBI:nicotine))
• a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:Neuroprotection)

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