a(HBP:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404))

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PubMed:22156579

We first confirmed that expression of an MKI-GFP fusion protein in rat hippocampal neurons effectively attenuated MARK4-mediated phosphorylation of both endogenous tau (Fig. 3A) and transfected human tau at the 12E8 sites (Fig. 3B). Phosphorylation of tau at the PHF-1 site was also reduced by MKI (Fig. 3A). It is possible that the PHF-1 site is also targeted by PAR-1/MARKs in vivo, or that the phosphorylation of tau at the 12E8 sites is a prerequisite for PHF-1 site phosphorylation, as the 12E8 sites were previously shown to be required for tau phosphorylation at other sites

Related Edges 9

• a(HBP:"Tau epitope, 12E8") positiveCorrelation a(HBP:"Tau epitope, PHF1")
• a(HBP:"Tau epitope, PHF1") positiveCorrelation a(HBP:"Tau epitope, 12E8")
• a(HBP:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396))
• p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation a(HBP:"Tau epitope, PHF1")
• p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation a(HBP:"Tau epitope, PHF1")
• p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin))
• p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin))
• act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
• act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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