path(MESH:D003071) negativeCorrelation r(HGNC:CHRNA7)

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PubMed:18986241

This increase in alpha7 nAChR expression levels within CBF neurons was inversely associated with cognitive performance. Increased alpha7 nAChR expression in CBF neurons may signal a compensatory response to maintain basocortical cholinergic activity during the onset of AD. Upregulation of the alpha7 nAChR within individual CBF neurons is also consistent with reports of increased alpha7 nAChR mRNA and protein expression levels in hippocampal neurons, astrocytes and peripheral blood leukocytes in AD [120–122]. The observed increase in alpha7 nAChR in early AD may regulate basocortical cholinergic tone through pre- and/or postsynaptic mechanisms within cholinergic NB neurons prior to their frank degeneration in the later stages of AD.

Related Edges 3

• path(MESH:D000544) increases r(HGNC:CHRNA7)
• r(HGNC:CHRNA7) negativeCorrelation path(MESH:D003071)
• r(HGNC:CHRNA7) regulates act(a(MESH:D059329))

Disease Ontology (DO)

Alzheimer's disease

MeSH

Astrocytes

MeSH

Hippocampus

MeSH

Leukocytes

MeSH

Cognitive Dysfunction

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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