complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC))

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PubMed:26813123

Stimulation of Gαq coupled muscarinic receptors leads to activation of phospholipase C and formation of inositol phosphates and other second messengers, which can promote closure of K+ channels, thus facilitating cell excitability

Related Edges 8

• complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC))
• complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol")
• complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels"))
• complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol")
• complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels"))
• complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC))
• complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol")
• complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels"))

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