a(CHEBI:"amyloid-beta polypeptide 42") regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))

PubMed:19126755

It is noteworthy that the alpha7 nAChR activity increases intracellular accumulation of Abeta in neurons (336), and Abeta peptides, in addition to modulating nAChR activity, downregulate the expression of nAChRs (197).

Related Edges 2

• a(CHEBI:"amyloid-beta polypeptide 42") decreases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
• act(p(HGNC:CHRNA7)) increases a(CHEBI:"amyloid-beta", loc(GO:intracellular))

MeSH

Neurons

Text Location

Review

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