path(HBP:neurotoxicity) association a(CHEBI:nicotine)

PubMed:19126755

Metabolic degradation of nicotine and rapid clearance is a mechanism that protects neurons from greater nicotine concentrations, since nicotine readily crosses the mammalian blood-brain barrier and accumulates in the lipophilic brain environment to concentrations that may exceed plasma concentrations by one order of magnitude. Nevertheless, neurotoxicity to nicotine is not uncommon, as attested to by the recent increase in hospital emergency room visits by smokers who concurrently use the transdermal nicotine patch (503).

Related Edges 2

• a(CHEBI:nicotine) association path(HBP:neurotoxicity)
• a(MESH:Neurons) increases deg(a(CHEBI:nicotine))

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