a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM1)

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PubMed:12578227

Protein and mRNA levels of transglutaminase 1 were increased in globus pallidus of PSP as compared to controls. There were also significantly higher mRNA levels of the short form of transglutaminase 2 in globus pallidus of PSP (974% of control). Transglutaminase 1 mRNA and the long isoform of transglutaminase 2 mRNA (2212% of control) were significantly higher in PSP in the dentate of cerebellum. Together, these findings suggest that transglutaminase 1 and 2 enzymes may be involved in the formation and/or stabilization of neurofibrillary tangles in selectively vulnerable brain regions in PSP. These transglutaminases may be potential targets for therapeutic intervention.

Related Edges 7

• a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM2)
• p(HGNC:TGM2) positiveCorrelation a(GO:"neurofibrillary tangle")
• p(HGNC:TGM1) positiveCorrelation a(GO:"neurofibrillary tangle")
• path(MESH:"Supranuclear Palsy, Progressive") increases p(HGNC:TGM1)
• path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM1)
• path(MESH:"Supranuclear Palsy, Progressive") increases r(HBP:"TGM2 Isoform 3 (349 aa)")
• path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM2)

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