a(CHEBI:paclitaxel) increases tloc(a(GO:autophagosome), fromLoc(GO:"extracellular space"), toLoc(MESH:Neurons))

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PubMed:29758300

Paclitaxel reversed Aβ-induced microtubule disruption and restored autophagosomal transport in neurons [161], while a similar compound, epothilone D/BMS-241027, reduced tauopathy and improved cognition in P301S transgenic mice [162] although the compound did not progress beyond Phase I clinical testing

Related Edges 3

• a(CHEBI:epothilone) decreases path(MESH:Tauopathies)
• a(CHEBI:epothilone) increases bp(GO:cognition)
• a(CHEBI:paclitaxel) increases a(GO:microtubule)

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