complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) decreases a(CHEBI:"amyloid-beta")

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PubMed:24590577

In fact, Abeta has been shown to induce the uncoupling of M1 mAChR from G-protein, antagonizing the function of M1 mAChR under the pathological conditions of AD[96, 97]. Such an uncoupling may result in decreased signal transduction, reduced levels of sAPPalpha, and increased production of Abeta, triggering a vicious cycle.

Related Edges 4

• a(CHEBI:"amyloid-beta") decreases complex(p(FPLX:"G_protein"), p(HGNC:CHRM1))
• a(CHEBI:"amyloid-beta") decreases act(p(HGNC:CHRM1))
• complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases a(HBP:"sAPP-alpha")
• complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases bp(GO:"signal transduction")

MeSH

Alzheimer Disease

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