a(CHEBI:curcumin) increases deg(p(HGNC:SNCA, var("p.Ala53Thr")))

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PubMed:30116051

The natural product curcumin induced macro- autophagy and protected rotenone-treated dopaminer- gic neurons 141 in addition to accelerating the elimination of mutant α-synuclein-A53T by repressing mTORC1 in a cellular model of early-onset PD, although it also exerts other actions such as inhibition of p300-mediated pro- tein acetylation and of aggregation 142,143 .

Related Edges 2

• a(CHEBI:curcumin) increases bp(GO:macroautophagy)
• a(CHEBI:curcumin) decreases act(p(FPLX:mTORC1))

MeSH

Dopaminergic Neurons

MeSH

Machado-Joseph Disease

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