a(CHEBI:nicotine) increases bp(GO:"ERK1 and ERK2 cascade")

View Subject View Object

PubMed:19293145

Furthermore, nicotinic activation of ERK-1/2 promotes survival of cultured murine spinal cord neurons, and the blocking of ERK-1 prevents nicotine’s antiapoptotic action (Toborek et al., 2007). Likewise, the alpha7-specific agonist A-582941 induces phosphorylation of ERK-1/2 in PC12 cells and in mouse brain, and this is completely blocked by the mitogen-activated protein kinase 1 inhibitor SL327 (Bitner et al., 2007).

Related Edges 4

• a(CHEBI:"SL-327") decreases act(a(MESH:"A-582941"))
• a(MESH:"A-582941") increases p(HGNC:MAPK3, pmod(Ph))
• a(MESH:"A-582941") increases p(HGNC:MAPK1, pmod(Ph))
• bp(GO:"ERK1 and ERK2 cascade") increases bp(GO:"apoptotic process")

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---