p(RGD:Cdk5r2) positiveCorrelation a(GO:synapse)

View Subject View Object

PubMed:27807169

p39, but not p35, is selectively upregulated by histone acetylation-mediated transcription, underlying the robust increase of Cdk5 activity during rat and mouse neuronal differentiation. Loss of p39 attenuates Cdk5 activity in neurons and preferentially affects phosphorylation of specific Cdk5 targets, leading to aberrant axonal growth and impaired dendritic spine and synapse formation.

Related Edges 4

• a(GO:"dendritic spine") positiveCorrelation p(RGD:Cdk5r2)
• a(GO:synapse) positiveCorrelation p(RGD:Cdk5r2)
• p(RGD:Cdk5r2) directlyIncreases act(p(RGD:Cdk5))
• p(RGD:Cdk5r2) positiveCorrelation a(GO:"dendritic spine")

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---