a(CHEBI:"amyloid-beta") increases p(RGD:Mapt, pmod(Sumo))

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PubMed:25378699

Furthermore, the enhanced SUMO-immunoreactivity, costained with the hyperphosphorylated tau, is detected in cerebral cortex of the AD brains, and β-amyloid exposure of rat primary hippocampal neurons induces a dose-dependent SUMOylation of the hyperphosphorylated tau. Our findings suggest that tau SUMOylation reciprocally stimulates its phosphorylation and inhibits the ubiquitination-mediated tau degradation, which provides a new insight into the AD-like tau accumulation.

Related Edges 5

• deg(p(HGNC:MAPT)) positiveCorrelation p(HGNC:MAPT, pmod(Ub))
• p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Sumo, Lys, 340))
• p(HGNC:MAPT, pmod(Sumo, Lys, 340)) positiveCorrelation p(HGNC:MAPT, pmod(Ph))
• p(HGNC:MAPT, pmod(Sumo, Lys, 340)) decreases p(HGNC:MAPT, pmod(Ub))
• p(HGNC:MAPT, pmod(Ub)) positiveCorrelation deg(p(HGNC:MAPT))

Uberon

hippocampal formation

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