act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT))

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PubMed:24027553

Soluble, monomeric tau is an ideal proteasomal substrate. Indeed, it has been clearly demonstrated that tau can be degraded by the proteasome (65–67, 73). It thus can be suggested that under physiologic circumstances much of tau is degraded in this manner, with select modified forms being cleared by autophagy.However, within the context of the AD milieu, additional tau modifications and degradative impairments may cause the balance to shift away from proteasomal degradation toward autophagy.

Related Edges 2

• bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates"))
• act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(HBP:"Tau aggregates"))

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