p(INTERPRO:"HECT domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3))

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PubMed:24457024

Both HECT and RBR E3s are unique in comparison to the RING ligases because they catalyze an additional transthioesterification step, where ubiquitin is transferred from the E2 to the E3 before its conjugation to the protein substrate (Figure 1A)

Related Edges 1

• p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3))

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