p(HGNC:BACE1, frag("67_78")) decreases sec(a(HBP:"sAPP-beta"))

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PubMed:17293005

BI-1 treatment dose-dependently inhibited the release of both sAPPa and sAPPb in the conditioned medium (Figs. 2A and 3A). The 50% inhibitory concentrations (IC50) of BI-1 were about 1.5 mM for sAPPa and 0.9 mM for APPb, respectively. But BI-2, which is mainly composed of the core region BACE1 69–73, did not show the inhibitory effects

Related Edges 3

• p(HGNC:BACE1, frag("67_78")) decreases sec(a(HBP:"sAPP-alpha"))
• p(HGNC:BACE1, frag("69_75")) causesNoChange sec(a(HBP:"sAPP-beta"))
• p(HGNC:BACE1, frag("69_75")) causesNoChange sec(a(HBP:"sAPP-alpha"))

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