g(HGNC:APOE) causesNoChange complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))

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PubMed:19293145

The APOE-epsilon4 gene-dose effect was also found to correlate with the loss of nAChR binding sites in patients with AD, as well as a reduced respon- siveness to the therapeutic AChE inhibitor tacrine (Poirier et al., 1995). Within an AD cohort, APOE-epsilon4 dose dependently correlates with higher losses of ChAT but not with losses in alpha4beta2 nAChRs (Lai et al., 2006).

Related Edges 6

• act(a(CHEBI:tacrine)) negativeCorrelation g(HGNC:APOE)
• act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association g(HGNC:APOE)
• g(HGNC:APOE) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
• g(HGNC:APOE) negativeCorrelation p(HGNC:CHAT)
• g(HGNC:APOE) negativeCorrelation act(a(CHEBI:tacrine))
• p(HGNC:CHAT) negativeCorrelation g(HGNC:APOE)

MeSH

Alzheimer Disease

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