complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP")

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PubMed:24590577

So far, five mAChR subtypes (M1– M5) have been identified and are divided into two categories based on the manner of signal transduction: M1, M3, and M5 subtypes preferentially interact with the Gq/11 family of G proteins, activating phospholipase C and mobilizing intracellular calcium, while M2 and M4 subtypes couple to the Go/i family, inhibiting adenylate cyclases and reducing intracellular cAMP levels

Related Edges 9

• complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases act(p(FPLX:PLC))
• complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport")
• complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases")
• complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP")
• complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases act(p(FPLX:PLC))
• complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport")
• complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases")
• complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases act(p(FPLX:PLC))
• complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport")

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