a(MESH:Trehalose) increases bp(MESH:Autophagy)

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PubMed:24027553

In a mouse model expressing the FTDP-17 mutant P301S, promoting autophagy with trehalose treatment beginning at weaning significantly reduced insoluble tau, as well as tau phosphorylated at T212/S214 (AT100) (97). However, no other phosphorylation sites were assessed. This effect was correlated with improved neuronal survival in cortical layers I–III (97).

Related Edges 5

• bp(GO:"neuron death") negativeCorrelation bp(MESH:Autophagy)
• bp(MESH:Autophagy) decreases p(MGI:Mapt, var("p.P301S"))
• bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(Ph, Thr, 212), var("p.P301S"))
• bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(Ph, Ser, 214), var("p.P301S"))
• bp(MESH:Autophagy) negativeCorrelation bp(GO:"neuron death")

MeSH

Frontotemporal Dementia

Text Location

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