act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT))

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PubMed:24027553

There is significant evidence that tau is a caspase substrate and that caspase-mediated tau cleavage may play a role in AD pathology. Early in vitro studies demonstrated that tau is cleaved in the C-terminus by several caspases including caspase-3 and caspase-6 (21–23).

Related Edges 2

• act(p(HGNC:CASP3)) increases p(HGNC:MAPT, frag("?_*"))
• act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*"))

MeSH

Alzheimer Disease

Text Location

Review

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