p(MGI:Ppp2ca, pmod(Me, Leu, 309)) decreases act(p(MGI:Ppp2ca))

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PubMed:28422052

Folic acid reduced tau hyperphosphorylation at Ser396 in the brain of diabetes mellitus (DM) mice. In addition, PP2A methylation and DNMT1 mRNA expression were significantly increased in DM mice post folic acid treatment. GSK-3β phosphorylation was not regulated by folic acid administration. Folic acid can reduce tau phosphorylation by regulating PP2A methylation in diabetic mice.

Related Edges 3

• a(CHEBI:"folic acid") decreases p(MGI:Mapt, pmod(Ph, Ser, 396))
• a(CHEBI:"folic acid") increases p(MGI:Dnmt1)
• p(MGI:Dnmt1) increases p(MGI:Ppp2ca, pmod(Me, Leu, 309))

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