act(p(HBP:RAC1b)) positiveCorrelation act(a(MESH:Neurons))

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PubMed:27087442

Our data showed that CDK5 knock down induced an increase in p35 protein levels and Rac activity in triple transgenic Alzheimer's mice, which correlated with the recovery of cognitive function; these findings confirm that increased p35 and active Rac are involved in neuroprotection. In summary, our data suggest that p35 acts as a mediator of Rho GTPase activity and contributes to the neuroprotection induced by CDK5 RNAi.

Related Edges 11

• act(a(MESH:Neurons)) positiveCorrelation p(MGI:Cdk5r1)
• act(a(MESH:Neurons)) positiveCorrelation act(p(HBP:RAC1b))
• act(a(MESH:Neurons)) negativeCorrelation p(MGI:Cdk5)
• act(p(HBP:RAC1b)) negativeCorrelation p(MGI:Cdk5)
• p(MGI:Cdk5) negativeCorrelation p(MGI:Cdk5r1)
• p(MGI:Cdk5) negativeCorrelation act(p(HBP:RAC1b))
• p(MGI:Cdk5) negativeCorrelation path(MESH:Cognition)
• p(MGI:Cdk5) negativeCorrelation act(a(MESH:Neurons))
• p(MGI:Cdk5r1) negativeCorrelation p(MGI:Cdk5)
• p(MGI:Cdk5r1) positiveCorrelation act(a(MESH:Neurons))
• path(MESH:Cognition) negativeCorrelation p(MGI:Cdk5)

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