p(HBP:"VQIVYK motif") increases bp(GO:"neurofibrillary tangle assembly")

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PubMed:23531502

CA and the oxidized form of EC (ECox) inhibited tau aggregation in vitro due to their interaction with the two cysteine residues in tau. A synthetic peptide, SKCGS, representing the actual tau sequence, identified the thiol as reacting with CA and ECox which necessitates of cysteine for aggregation inhibition by CA.

Related Edges 6

• a(CHEBI:"(-)-epicatechin") decreases bp(GO:"neurofibrillary tangle assembly")
• a(CHEBI:"(-)-epicatechin") decreases p(HBP:"KXGS motif")
• a(CHEBI:cinnamaldehyde) decreases p(HBP:"KXGS motif")
• a(CHEBI:cinnamaldehyde) decreases bp(GO:"neurofibrillary tangle assembly")
• p(HBP:"KXGS motif") positiveCorrelation p(HBP:"VQIVYK motif")
• p(HBP:"VQIVYK motif") positiveCorrelation p(HBP:"KXGS motif")

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