complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG))

PubMed:19126755

Green and colleagues (191, 365, 485) report that nAChR assembly proceeds in the endoplasmic reticulum where specific subunits are added sequentially to the receptor complex according to the conformations the complex assumes. In this model, nAChR subunits are synthesized, and initial polypeptide folding favors the rapid recognition and interaction between alpha-beta-gamma subunits to produce trimers that in turn form a structure favorable to the addition of the delta subunit and finally the second alpha subunit.

Related Edges 2

• complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG))
• composite(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.