act(p(HGNC:CHRM1)) decreases act(p(HGNCGENEFAMILY:Caspases))

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PubMed:24590577

Activation of M1 mAChR also protects against apoptotic factors in human neuroblastoma SH-SY5Y cells, such as DNA damage, oxidative stress, caspase activation, and mitochondrial impairment[83]. In addition, apoptosis induced by serum deprivation is blocked by M1 mAChR activation in a phosphoinositide 3-kinase- and MAPK/ERKindependent manner

Related Edges 3

• act(p(HGNC:CHRM1)) decreases bp(GO:"cell death")
• act(p(HGNC:CHRM1)) decreases path(MESH:"DNA Damage")
• act(p(HGNC:CHRM1)) decreases path(MESH:"Oxidative Stress")

Experimental Factor Ontology (EFO)

SH-SY5Y

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