r(MGI:Dnm1l) positiveCorrelation p(MGI:Mapt, pmod(Ph))

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PubMed:28173111

Mitochondrial dysfunction found to be reduced in TauXDrp1þ/+- mice relative to Tau mice. Phosphorylated Tau levels were significantly reduced in TauXDrp1þ/+- mice relative to Tau mice. These findings suggest that a partial reduction of Drp1 decreases the levels of phosphorylated Tau, reduces mitochondrial dysfunction, and maintains mitochondrial dynamics, enhances mitochondrial biogenesis and synaptic activity in Tau mice.

Related Edges 9

• bp(MESH:"Mitochondrial Dynamics") negativeCorrelation r(MGI:Dnm1l)
• r(MGI:Dnm1l) negativeCorrelation act(complex(GO:"neuron to neuron synapse"))
• act(complex(GO:"neuron to neuron synapse")) negativeCorrelation r(MGI:Dnm1l)
• act(complex(GO:mitochondrion)) negativeCorrelation r(MGI:Dnm1l)
• complex(GO:mitochondrion) negativeCorrelation r(MGI:Dnm1l)
• p(MGI:Mapt, pmod(Ph)) positiveCorrelation r(MGI:Dnm1l)
• r(MGI:Dnm1l) negativeCorrelation act(complex(GO:mitochondrion))
• r(MGI:Dnm1l) negativeCorrelation complex(GO:mitochondrion)
• r(MGI:Dnm1l) negativeCorrelation bp(MESH:"Mitochondrial Dynamics")

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