a(MESH:"3-methyladenine") increases p(HGNC:MAPT, frag("?"))

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PubMed:24027553

Overexpressing only the repeat domain of tau containing an FTDP-17 mutation in neuroblastoma cells leads to tau aggregation as well as the appearance of smaller proteolytic fragments. Using the autophagy inhibitor 3-methyladenine (3-MA) to block the formation of autophagosomes led to an increase in both soluble and insoluble tau (94).

Related Edges 2

• a(MESH:"3-methyladenine") decreases bp(MESH:Autophagy)
• p(HGNC:MAPT, frag("561_685")) increases a(HBP:"Tau aggregates")

MeSH

Frontotemporal Dementia

Text Location

Review

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