complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Huntington Disease")

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PubMed:14556719

Accumulation of ubiquitin conjugates and/or inclusion bodies associated with ubiquitin, proteasome, and certain disease-characteristic proteins have been reported in a broad array of chronic neurodegenerative diseases, such as the neurofibrillary tangles of Alzheimer’s disease (AD), brainstem Lewy bodies (LBs) (the neuropathological hallmark in Parkinson’s disease [PD]), Bunina bodies in Amyotrophic Lateral Sclerosis (ALS), and nuclear inclusions in CAG repeat expansion (polyglutamine/Q extension) disorders such as Huntington’s disease, Spinocerebellar Ataxias (SCAs), and Spinal and Bulbar Muscular Atrophy (SBMA; Kennedy’s disease) (reviewed recently by Alves-Rodrigues et al., 1998; Sherman and Goldberg, 2001) (Figure 2)

Related Edges 23

• a(GO:"Bunina body") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin))
• a(GO:"Bunina body") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies"))
• a(MESH:"Lewy Bodies") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin))
• a(MESH:"Lewy Bodies") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies"))
• a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin))
• a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies"))
• complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Neurofibrillary Tangles")
• complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(GO:"Bunina body")
• complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Spinocerebellar Ataxias")
• complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked")
• complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Lewy Bodies")
• complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Neurofibrillary Tangles")
• complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(GO:"Bunina body")
• complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Huntington Disease")
• complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Spinocerebellar Ataxias")
• complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked")
• complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Lewy Bodies")
• path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin))
• path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies"))
• path(MESH:"Huntington Disease") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin))
• path(MESH:"Huntington Disease") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies"))
• path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin))
• path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies"))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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