a(CHEBI:xanomeline) increases bp(GO:cognition)

PubMed:24511233

Of these, the M1/M4 -preferring agonist xanomeline was the only one to progress to a phase III clinical trial, where it was assessed for efficacy in ameliorating cognitive deficits observed in AD patients. While xanomeline showed a trend toward improving cognitive function in these patients, this effect did not reach statistical significance. However, this agonist did produce surprisingly robust and dose-dependent reductions in hallucinations, delusions, vocal outbursts, and other behavioral disturbances in these patients

Related Edges 2

• a(CHEBI:xanomeline) decreases path(MESH:Hallucinations)
• a(CHEBI:xanomeline) decreases path(MESH:Delusions)

MeSH

Alzheimer Disease

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