p(HBP:"Tau C3") increases bp(GO:"apoptotic process")

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PubMed:24027553

There may be reciprocity with the apoptosis pathway as activating caspase-3 by inducing apoptosis in cortical neuronal culture led to tau cleavage (22), and selectively expressing tauC3 led to apoptosis in NT2 and COS cells (21). This might represent a feed-forward loop of neurotoxicity.

Related Edges 3

• bp(GO:"apoptotic process") increases act(p(HGNC:CASP6))
• act(p(HGNC:CASP3)) increases deg(p(HGNC:MAPT))
• act(p(HGNC:CASP3)) increases p(HBP:"Tau C3")

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